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Abstract
The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.
Authors
Derek Gordon, Stephen J. Finch
Figure 1
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Pictorial example of recombination. Left: The 2 pairs of chromosomes (solid lines, dashed lines) represent the (duplicated) chromosomes in meiosis before recombination takes place. Right: The set of chromosomes after recombination has taken place. The first and last chromosomes are nonrecombinant, since they are identical to chromosomes on the left. The second and third chromosomes on the right are recombinant, since each contains a portion of the chromosomes on the left. Note that the recombination takes place between the first and second locus.
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ISSN: 0021-9738 (print), 1558-8238 (online)