Death begets failure in the heart
Roger S.-Y. Foo, … , Kartik Mani, Richard N. Kitsis
Roger S.-Y. Foo, … , Kartik Mani, Richard N. Kitsis
Published March 1, 2005
Citation Information: J Clin Invest. 2005;115(3):565-571. https://doi.org/10.1172/JCI24569.
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Review Series

Death begets failure in the heart

Abstract

Recently, low — but abnormal — rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

Authors

Roger S.-Y. Foo, Kartik Mani, Richard N. Kitsis

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