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Research Article Free access | 10.1172/JCI2250

Role of interleukin 10 in specific immunotherapy.

C A Akdis, T Blesken, M Akdis, B Wüthrich, and K Blaser

Swiss Institute of Allergy and Asthma Research, CH-7270 Davos, Switzerland. akdisac@isac@siaf.unizh.ch

Find articles by Akdis, C. in: JCI | PubMed | Google Scholar

Swiss Institute of Allergy and Asthma Research, CH-7270 Davos, Switzerland. akdisac@isac@siaf.unizh.ch

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Swiss Institute of Allergy and Asthma Research, CH-7270 Davos, Switzerland. akdisac@isac@siaf.unizh.ch

Find articles by Akdis, M. in: JCI | PubMed | Google Scholar

Swiss Institute of Allergy and Asthma Research, CH-7270 Davos, Switzerland. akdisac@isac@siaf.unizh.ch

Find articles by Wüthrich, B. in: JCI | PubMed | Google Scholar

Swiss Institute of Allergy and Asthma Research, CH-7270 Davos, Switzerland. akdisac@isac@siaf.unizh.ch

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Published July 1, 1998 - More info

Published in Volume 102, Issue 1 on July 1, 1998
J Clin Invest. 1998;102(1):98–106. https://doi.org/10.1172/JCI2250.
© 1998 The American Society for Clinical Investigation
Published July 1, 1998 - Version history
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Abstract

The induction of allergen-specific anergy in peripheral T cells represents a key step in specific immunotherapy (SIT). Here we demonstrate that the anergic state results from increased IL-10 production. In bee venom (BV)-SIT the specific proliferative and cytokine responses against the main allergen, the phospholipase A2 (PLA), and T cell epitope-containing PLA peptides were significantly suppressed after 7 d of treatment. Simultaneously, the production of IL-10 increased during BV-SIT. After 28 d of BV-SIT the anergic state was established. Intracytoplasmic cytokine staining of PBMC combined with surface marker detection revealed that IL-10 was produced initially by activated CD4(+)CD25(+), allergen-specific T cells, and followed by B cells and monocytes. Neutralization of IL-10 in PBMC fully reconstituted the specific proliferative and cytokine responses. A similar state of IL-10-associated T cell anergy, as induced in BV-SIT, was found in hyperimmune individuals who recently had received multiple bee stings. The addition of IL-10 to soluble CD40 ligand IL-4-stimulated PBMC or purified B cells inhibited the PLA-specific and total IgE and enhanced the IgG4 formation. Accordingly, increased IL-10 production by SIT causes specific anergy in peripheral T cells, and regulates specific IgE and IgG4 production toward normal IgG4-related immunity.

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