Advertisement

Research Article Free access | 10.1172/JCI2172

Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model.

D A Barnes, J Tse, M Kaufhold, M Owen, J Hesselgesser, R Strieter, R Horuk, and H D Perez

Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA. debra_barnes@berlex.com

Find articles by Barnes, D. in: PubMed | Google Scholar

Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA. debra_barnes@berlex.com

Find articles by Tse, J. in: PubMed | Google Scholar

Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA. debra_barnes@berlex.com

Find articles by Kaufhold, M. in: PubMed | Google Scholar

Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA. debra_barnes@berlex.com

Find articles by Owen, M. in: PubMed | Google Scholar

Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA. debra_barnes@berlex.com

Find articles by Hesselgesser, J. in: PubMed | Google Scholar

Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA. debra_barnes@berlex.com

Find articles by Strieter, R. in: PubMed | Google Scholar

Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA. debra_barnes@berlex.com

Find articles by Horuk, R. in: PubMed | Google Scholar

Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA. debra_barnes@berlex.com

Find articles by Perez, H. in: PubMed | Google Scholar

Published June 15, 1998 - More info

Published in Volume 101, Issue 12 on June 15, 1998
J Clin Invest. 1998;101(12):2910–2919. https://doi.org/10.1172/JCI2172.
© 1998 The American Society for Clinical Investigation
Published June 15, 1998 - Version history
View PDF
Abstract

Adjuvant-induced arthritis (AIA) is one of many animal models of rheumatoid arthritis, a disease characterized by a T-lymphocyte and macrophage cellular infiltrate. We have characterized the development of this disease model with respect to chemokine expression. Increased levels of two chemokines, RANTES, a T-lymphocyte and monocyte chemo-attractant, and KC a chemoattractant for neutrophils, were found in whole blood and in the joint. Surprisingly, levels of MIP-1alpha, another T-lymphocyte and monocyte chemoattractant, were unchanged throughout the course of the disease in whole blood and only slightly elevated in the joint. RANTES expression plays an important role in the disease since a polyclonal antibody to RANTES greatly ameliorated symptoms in animals induced for AIA and was found to be as efficacious as treatment with indomethacin, a non-steroidal anti inflammatory. Polyclonal antibodies to either MIP-1alpha or KC were ineffective. This is the first report to show the importance of RANTES in the development of AIA.

Version history
  • Version 1 (June 15, 1998): No description
Advertisement
Advertisement