Combined loss of histone methyltransferases GLP and G9a disrupts neural crest cell fate determination

Diana B. Voss; Emily J. Shields; Andrey Poleshko; Li Li; Jun Li; Roger Wang; Mariacristina Calcagno; Rajan Jain; Cheryl L. Smith; Jonathan A. Epstein

doi:10.1172/JCI205970

¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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J Clin Invest. https://doi.org/10.1172/JCI205970.
Copyright © 2026, Voss et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Published August 13, 2026 - Version history

Combined loss of histone methyltransferases GLP and G9a disrupts neural crest cell fate determination

Diana B. Voss,¹ Emily J. Shields,¹ Andrey Poleshko,¹ Li Li,¹ Jun Li,¹ Roger Wang,¹ Mariacristina Calcagno,¹ Rajan Jain,¹ Cheryl L. Smith,¹ and Jonathan A. Epstein¹

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Combined loss of histone methyltransferases GLP and G9a disrupts neural crest cell fate determination

Diana B. Voss,1 Emily J. Shields,1 Andrey Poleshko,1 Li Li,1 Jun Li,1 Roger Wang,1 Mariacristina Calcagno,1 Rajan Jain,1 Cheryl L. Smith,1 and Jonathan A. Epstein1

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Diana B. Voss,¹ Emily J. Shields,¹ Andrey Poleshko,¹ Li Li,¹ Jun Li,¹ Roger Wang,¹ Mariacristina Calcagno,¹ Rajan Jain,¹ Cheryl L. Smith,¹ and Jonathan A. Epstein¹