MANF clears mutant uromodulin in human kidney organoids of autosomal dominant tubulointerstitial kidney disease

Chenjian Gu; Yili Fang; Yixuan Wang; Eric Tycksen; Gayathri Kondepati; Chuang Li; Kendrah O. Kidd; Jun Liu; Fumihiko Urano; Maria Lindahl; Anthony J. Bleyer; Srikanth Singamaneni; Zhao Sun; Ying Maggie Chen

doi:10.1172/JCI205631

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Gu, C. in: PubMed | Google Scholar

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Fang, Y. in: PubMed | Google Scholar

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Wang, Y. in: PubMed | Google Scholar

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

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¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

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¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Li, C. in: PubMed | Google Scholar

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

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¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Liu, J. in: PubMed | Google Scholar

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Urano, F. in: PubMed | Google Scholar |

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Lindahl, M. in: PubMed | Google Scholar

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Bleyer, A. in: PubMed | Google Scholar

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Singamaneni, S. in: PubMed | Google Scholar

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Sun, Z. in: PubMed | Google Scholar

¹Department of Medicine, Washington University School of Medicine, St Louis, United States of America

²Department of Medicine, Washington University School of Medicine, St. Louis, United States of America

³Institute of Materials Science and Engineering, Washington University School of Medicine, St. Louis, United States of America

⁴Genome Technology Access Center, Washington University School of Medicine, St. Louis, United States of America

⁵Department of Medicine, Wake Forest University, Winston-Salem, United States of America

⁶Shanghai General Hospital, Shanghai, China

⁷Institute of Biotechnlogy, University of Helsinki, Helsinki, Finland

⁸Department of Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America

⁹Institute of Materials Science and Engineering, Washington University School of Medicine, Saint Louis, United States of America

¹⁰Department of Biological Sciences, The University of Texas at Dallas, Richardson, United States of America

Find articles by Chen, Y. in: PubMed | Google Scholar

MANF clears mutant uromodulin in human kidney organoids of autosomal dominant tubulointerstitial kidney disease

Chenjian Gu,¹ Yili Fang,¹ Yixuan Wang,³ Eric Tycksen,⁴ Gayathri Kondepati,³ Chuang Li,¹ Kendrah O. Kidd,⁵ Jun Liu,⁶ Fumihiko Urano,¹ Maria Lindahl,⁷ Anthony J. Bleyer,⁸ Srikanth Singamaneni,³ Zhao Sun,¹⁰ and Ying Maggie Chen¹

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MANF clears mutant uromodulin in human kidney organoids of autosomal dominant tubulointerstitial kidney disease

Chenjian Gu,1 Yili Fang,1 Yixuan Wang,3 Eric Tycksen,4 Gayathri Kondepati,3 Chuang Li,1 Kendrah O. Kidd,5 Jun Liu,6 Fumihiko Urano,1 Maria Lindahl,7 Anthony J. Bleyer,8 Srikanth Singamaneni,3 Zhao Sun,10 and Ying Maggie Chen1

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Chenjian Gu,¹ Yili Fang,¹ Yixuan Wang,³ Eric Tycksen,⁴ Gayathri Kondepati,³ Chuang Li,¹ Kendrah O. Kidd,⁵ Jun Liu,⁶ Fumihiko Urano,¹ Maria Lindahl,⁷ Anthony J. Bleyer,⁸ Srikanth Singamaneni,³ Zhao Sun,¹⁰ and Ying Maggie Chen¹