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ResearchIn-Press PreviewGastroenterologyMetabolism
Open Access | 
10.1172/JCI202709
Inhibiting menin attenuates high-fat diet-induced weight gain by limiting intestinal lipid absorption in mice
Xiaoru Cao,1 Pingping Zhou,1 Haiyue Meng,1 Zhitao Guo,1 Yan Cao,2 Chenghao Wang,1 Lulu Liu,1 Yinghao Guo,1 Yue Wang,3 Guoshun Xin,1 Dabin Liu,4 Feng Geng,5 and Jian Ma1
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Cao, X. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
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1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
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1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Guo, Z. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Cao, Y. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Wang, C. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Liu, L. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Guo, Y. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Wang, Y. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Xin, G. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Liu, D. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Find articles by Geng, F. in: PubMed | Google Scholar
1Department of Immunology, Harbin Medical University, Harbin, China
2Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
3Department of Immunology, Harbin Medical Universtiy, Harbin, China
4NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Affiliated Hospital Harbin Medical University, Harbin, China
5Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
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Published August 11, 2026 - More info
Copyright © 2026, Cao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)