17β-Estradiol counteracts pathological microtubule remodeling to enhance right ventricular function in preclinical models

¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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¹Lillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, United States of America

²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Med, National Jewish Health, Denver, United States of America

³Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, United States of America

⁴Experimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, United States of America

⁵Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, United States of America

⁶Gazes Cardiac Research Institute, Division of Cardiology, Department of Med, Medical University of South Carolina, Charleston, United States of America

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