Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model

¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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¹Clinic of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany

²Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg

³Institute of Physiology II, University of Bonn, Bonn, Germany

⁴Translational Biogerontology, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

⁵Department of Biotherapy, Sichuan University, Chengdu, China

⁶Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States of America

⁷Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

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