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ResearchIn-Press PreviewDevelopmentGenetics
Open Access | 
10.1172/JCI199043
HER2 deficiency causes a developmental disorder with growth retardation and craniofacial malformations
Huaxiang Zhao,1 Pan Wang,2 Yuhua Jiao,1 Huimei Huang,3 Min Yu,4 Qing He,5 Chengkai Pan,5 Shuang Guo,6 Wenbin Huang,7 Yunfei Jia,1 Qianying Kong,8 Huifang Peng,8 Yandong Han,1 Yuxia Hou,1 Zhanping Ren,1 Yongwei Tao,1 Fei Huang,9 Hongwei Jiang,8 Shan Sun,10 Yanying Dong,11 Jiuxiang Lin,12 Chunyan Yin,6 Xuechen Zhu,13 Feng Chen,14 and Yi Ding11
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Zhao, H. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Wang, P. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Jiao, Y. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Huang, H. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Yu, M. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by He, Q. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Pan, C. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Guo, S. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Huang, W. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Jia, Y. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Kong, Q. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Peng, H. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Han, Y. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Hou, Y. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Ren, Z. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Tao, Y. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Huang, F. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Jiang, H. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Sun, S. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Dong, Y. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Lin, J. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Yin, C. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Zhu, X. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Chen, F. in: PubMed | Google Scholar
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Rese, College of Stomatology, Xi’an Jiaotong University, Xi'an, China
2Research Center for Industries of the Future, Westlake University, Zhejiang, China
3Department of Nephrology, Xi'an Children’s Hospital, The Affiliated Children's Hospital, Xi’an Jiaotong University, Xi'an, China
4Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
6Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
7Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Guangdong, China
8Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China
9Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer,, The First Affiliated Hospital, Fujian Medical University, Fujian, China
10State Key Laboratory of Membrane Biology, Beijing Frontier Research Center, School of Life Sciences, Tsinghua University, Beijing, China
11Department of Transfusion Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
12Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China
13State Key Laboratory of Female Fertility Promotion, Department of Human Ana, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
14Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China
Find articles by Ding, Y. in: PubMed | Google Scholar
Published April 30, 2026 - More info
Copyright © 2026, Zhao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)