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ResearchIn-Press PreviewImmunologyOncology
Open Access | 
10.1172/JCI196907
A fungal-derived cyclic peptide enhances Th9-mediated antitumor immunity by targeting ZAP70 and SREBP1
Wenli Zhao,1 Yang Zhou,1 Yuyang Chen,1 Yicheng Sun,1 Jiaxin Tang,2 Yihan Zhu,1 Jie Ren,1 Tianxu Du,2 Handuo Wang,1 Yuan Gao,1 Yu Hu,3 Ling Jiang,4 Tomohiko Ohwada,5 Qi Luo,5 and Enguang Bi1
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Zhao, W. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Zhou, Y. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Chen, Y. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Sun, Y. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Tang, J. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Zhu, Y. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Ren, J. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Du, T. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Wang, H. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Gao, Y. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Hu, Y. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Jiang, L. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Ohwada, T. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Luo, Q. in: PubMed | Google Scholar
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
2Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Gu, Guangzhou, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Find articles by Bi, E. in: PubMed | Google Scholar
Published December 9, 2025 - More info
Copyright © 2025, Zhao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)