Advertisement
ResearchIn-Press PreviewGastroenterologyHepatology
Open Access | 
10.1172/JCI196730
Epigenetically controlled endothelial promyelocytic leukemia drives liver inflammation and fibrosis
Can Gan,1 Enjiang Lai,1 Yang Tai,1 Shuai Chen,2 Chong Zhao,1 Wenting Dai,1 Zhu Yang,1 Bei Li,3 Tian Lan,1 Yang Xiao,1 Yangkun Guo,1 Jiaxin Chen,1 Bo Wei,1 Zhaodi Che,4 Sheng Cao,5 Mengfei Liu,6 Frank Tacke,7 Chengwei Tang,1 Vijay H. Shah,5 Haopeng Yu,8 Fei Wang,4 Zhiyin Huang,1 and Jinhang Gao1
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Gan, C. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Lai, E. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Tai, Y. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Chen, S. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Zhao, C. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Dai, W. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Yang, Z. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Li, B. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Lan, T. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Xiao, Y. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Guo, Y. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by
Chen, J.
in:
PubMed
|
Google Scholar
|
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Wei, B. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Che, Z. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by
Cao, S.
in:
PubMed
|
Google Scholar
|
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Liu, M. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by
Tacke, F.
in:
PubMed
|
Google Scholar
|
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Tang, C. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Shah, V. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Yu, H. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Wang, F. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Huang, Z. in: PubMed | Google Scholar
1Department of Gastroenterology, Lab of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
3Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, China
4The First Affiliated Hospital, Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University, Guangzhou, China
5Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States of America
6Division of Digestive Disease, Internal Medicine, Yale University, New Haven, United States of America
7Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
8West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China
Find articles by Gao, J. in: PubMed | Google Scholar
Published March 17, 2026 - More info
Copyright © 2026, Gan et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)