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Usage Information

Citrullination in tumor immunity and therapy
Michael R. Pitter, Weiping Zou
Michael R. Pitter, Weiping Zou
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Review

Citrullination in tumor immunity and therapy

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Abstract

Peptidyl arginine deiminases (PADs) catalyze the conversion of arginine residues into peptidyl citrulline, a posttranslational modification known as protein citrullination (or arginine deimination). This process alters the charge of proteins from positive to neutral, thereby affecting their folding, stability, conformation, and function. PAD2 and PAD4 can translocate into the nucleus and citrullinate both cytoplasmic and nuclear proteins. In this Review, we focus on PAD2- and PAD4-mediated citrullination in immune cell subsets within the tumor microenvironment. We discuss how citrullination regulates immune cell function and tumor immunity and explore the potential of targeting citrullination as a strategy for cancer immunotherapy.

Authors

Michael R. Pitter, Weiping Zou

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Usage data is cumulative from October 2025 through July 2026.

Usage JCI PMC
Text version 4,911 498
PDF 1,006 159
Figure 883 3
Table 180 0
Citation downloads 242 0
Totals 7,222 660
Total Views 7,882

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ISSN: 0021-9738 (print), 1558-8238 (online)

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