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ResearchIn-Press PreviewImmunologyInfectious disease
Open Access | 10.1172/JCI190107
1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
Find articles by Zumbo, P. in: PubMed | Google Scholar
1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
Find articles by Billips, A. in: PubMed | Google Scholar
1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
Find articles by Mar, K. in: PubMed | Google Scholar
1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
Find articles by Yu, Y. in: PubMed | Google Scholar
1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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Heung, L.
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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1Infectious Disease Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States of America
4mmunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, United States of America
5Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America
6Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, United States of America
7Department of Medicine and Department of Biomedical Sciences, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
8Applied Bioinformatics Core, Division of Hematology and Medical Oncology, D, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, United States of America
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Hohl, T.
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Published August 5, 2025 - More info
Aspergillus fumigatus is the most common cause of invasive aspergillosis (IA), a devastating infection in immunocompromised patients. Plasmacytoid dendritic cells (pDCs) regulate host defense against IA by enhancing neutrophil antifungal properties in the lung. Here, we define the pDC activation trajectory during A. fumigatus infection and the molecular events that underlie the protective pDC - neutrophil crosstalk. Fungus-induced pDC activation begins after bone marrow egress and results in pDC-dependent regulation of lung type I and type III IFN levels. These pDC-derived products act on type I and type III IFN receptor-expressing neutrophils and control neutrophil fungicidal activity and reactive oxygen species production via STAT1 signaling in a cell-intrinsic manner. Mechanistically, neutrophil STAT1 signaling regulates the transcription and expression of Cybb, which encodes one of five NADPH oxidase subunits. Thus, pDCs regulate neutrophil-dependent immunity against inhaled molds by controlling the local expression of a subunit required for NADPH oxidase assembly and activity in the lung.