Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Aging (Upcoming)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • Gut-Brain Axis (Jul 2021)
    • Tumor Microenvironment (Mar 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Version history
  • Article usage
  • Citations to this article

Advertisement

CorrigendumImmunology Free access | 10.1172/JCI18817C1

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

Guillermina Girardi, Jessica Berman, Patricia Redecha, Lynn Spruce, Joshua M. Thurman, Damian Kraus, Travis J. Hollmann, Paolo Casali, Michael C. Caroll, Rick A. Wetsel, John D. Lambris, V. Michael Holers, and Jane E. Salmon

Find articles by Girardi, G. in: JCI | PubMed | Google Scholar

Find articles by Berman, J. in: JCI | PubMed | Google Scholar

Find articles by Redecha, P. in: JCI | PubMed | Google Scholar

Find articles by Spruce, L. in: JCI | PubMed | Google Scholar

Find articles by Thurman, J. in: JCI | PubMed | Google Scholar

Find articles by Kraus, D. in: JCI | PubMed | Google Scholar

Find articles by Hollmann, T. in: JCI | PubMed | Google Scholar

Find articles by Casali, P. in: JCI | PubMed | Google Scholar

Find articles by Caroll, M. in: JCI | PubMed | Google Scholar

Find articles by Wetsel, R. in: JCI | PubMed | Google Scholar

Find articles by Lambris, J. in: JCI | PubMed | Google Scholar

Find articles by Holers, V. in: JCI | PubMed | Google Scholar

Find articles by Salmon, J. in: JCI | PubMed | Google Scholar

Published February 15, 2004 - More info

Published in Volume 113, Issue 4 on February 15, 2004
J Clin Invest. 2004;113(4):646–646. https://doi.org/10.1172/JCI18817C1.
© 2004 The American Society for Clinical Investigation
Published February 15, 2004 - Version history
View PDF

Related article:

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
Guillermina Girardi, … , V. Michael Holers, Jane E. Salmon
Guillermina Girardi, … , V. Michael Holers, Jane E. Salmon
Article Immunology

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

  • Text
  • PDF
Abstract

Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in the presence of antiphospholipid (aPL) Ab’s. Currently, therapy for pregnant women with APS is focused on preventing thrombosis, but anticoagulation is only partially successful in averting miscarriage. We hypothesized that complement activation is a central mechanism of pregnancy loss in APS and tested this in a model in which pregnant mice receive human IgG containing aPL Ab’s. Here we identify complement component C5 (and particularly its cleavage product C5a) and neutrophils as key mediators of fetal injury, and we show that Ab’s or peptides that block C5a–C5a receptor interactions prevent pregnancy complications. The fact that F(ab)′2 fragments of aPL Ab’s do not mediate fetal injury and that C4-deficient mice are protected from fetal injury suggests that activation of the complement cascade is initiated via the classical pathway. Studies in factor B–deficient mice, however, indicate that alternative pathway activation is required and amplifies complement activation. In contrast, activating FcγRs do not play an important role in mediating aPL Ab–induced fetal injury. Our findings identify the key innate immune effectors engaged by pathogenic autoantibodies that mediate poor pregnancy outcomes in APS and provide novel and important targets for prevention of pregnancy loss in APS.

Authors

Guillermina Girardi, Jessica Berman, Patricia Redecha, Lynn Spruce, Joshua M. Thurman, Damian Kraus, Travis J. Hollmann, Paolo Casali, Michael C. Caroll, Rick A. Wetsel, John D. Lambris, V. Michael Holers, Jane E. Salmon

×

Original citation: J. Clin. Invest.112:1644–1654 (2003). doi:10.1172/JCI18817.

Citation for this corrigendum: J. Clin. Invest.113:646 (2004). doi:10.1172/JCI18817C1.

During the preparation of this manuscript for publication, an error was included in the Acknowledgments section. The corrected Acknowledgments appears below.

This research was supported by the Alliance for Lupus Research (J.E. Salmon and V.M. Holers), the Mary Kirkland Center for Lupus Research (J.E. Salmon), the S.L.E. Foundation Inc. (J.E. Salmon),the National Kidney Foundation (J.M. Thurman), and NIH grants AI-31105 (to V.M. Holers), AI-25011 (to R.A. Wetsel), and GM-62134 (to J.D. Lambris).

Version history
  • Version 1 (February 15, 2004): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Version history
Advertisement
Advertisement

Copyright © 2022 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts