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ResearchIn-Press PreviewImmunologyInfectious disease
Open Access | 
10.1172/JCI183541
MPO-anchored ENO1 mediates neutrophil extracellular trap DNA for enhancing Treg differentiation via IFITM2 during sepsis
Yi Jiang,1 Shenjia Gao,1 Xiya Li,1 Hao Sun,1 Xinyi Wu,1 Jiahui Gu,1 Zhaoyuan Chen,1 Han Wu,1 Xiaoqiang Zhao,2 Tongtong Zhang,2 Ronen Ben-Ami,3 Yuan Le,4 Timothy R. Billiar,5 Changhong Miao,1 Jie Zhang,1 Jun Wang,2 and Wankun Chen1
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Jiang, Y. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Gao, S. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Li, X. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Sun, H. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Wu, X. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Gu, J. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Chen, Z. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Wu, H. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Zhao, X. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Zhang, T. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Ben-Ami, R. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Le, Y. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Billiar, T. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Miao, C. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Zhang, J. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Wang, J. in: PubMed | Google Scholar
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Department of Integrative Medicine and Neurobiology, School of Basic Medica, Shanghai Medical College, Fudan University, Shanghai, China
3Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
4Department of Anesthesiology and Hunan Province Key Laboratory of Brain Hom, Third Xiangya Hospital, Central South University, Hunan, China
5Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
Find articles by Chen, W. in: PubMed | Google Scholar
Published September 2, 2025 - More info
Copyright © 2025, Jiang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)