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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
Find articles by Bodansky, A. in: JCI | PubMed | Google Scholar |
1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
Find articles by Asaki, J. in: JCI | PubMed | Google Scholar
1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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1Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, United States of America
2Diabetes Center, School of Medicine, UCSF, San Francisco, United States of America
3Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, United States of America
4Institute of Immunity, Transplantation, and Infection, Stanford University, Stanford, United States of America
5Fred Hutchinson Cancer Center, University of Washington School of Medicine, Seattle, United States of America
6Department of Biochemistry and Biophysics, UCSF, San Francisco, United States of America
7Biomedical Sciences Program, UCSF, San Francisco, United States of America
8Chan-Zuckerberg Biohub SF, San Francisco, United States of America
9Chan Zuckerberg Biohub SF, San Francisco, United States of America
10Department of Neurology, Yale School of Medicine, New Haven, United States of America
11Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
12Department of Neurology, Weill Institute for Neurosciences, UCSF, San Francisco, United States of America
13Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States of America
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Published May 16, 2024 - More info
Given the global surge in autoimmune diseases, it is critical to evaluate emerging therapeutic interventions. Despite numerous new targeted immunomodulatory therapies, comprehensive approaches to apply and evaluate the effects of these treatments longitudinally are lacking. Here, we leveraged advances in programmable-phage immunoprecipitation (PhIP-Seq) methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease. Using a custom set of over 730,000 human derived peptides, we demonstrated that each individual, regardless of disease state, possesses a distinct and complex constellation of autoreactive antibodies. For each individual, the set of resulting autoreactivites constituted a unique immunological fingerprint, or "autoreactome,” that was remarkably stable over years. Using the autoreactome as a primary output, we evaluated the relative effectiveness of various immunomodulatory therapies in altering autoantibody repertoires. We found that therapies targeting B-Cell Maturation Antigen (BCMA) profoundly altered an individual’s autoreactome, while anti-CD19 and CD20 therapies had minimal effects. These data both confirm that the autoreactome is comprised of autoantibodies secreted by plasma cells, and strongly suggest that BCMA or other plasma cell targeting therapies may be highly effective in treating currently refractory autoantibody mediated diseases.