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ResearchIn-Press PreviewEndocrinologyMetabolism
Open Access | 
10.1172/JCI179845
Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis
Xin Li,1 Jingxin Hu,1 Yumeng Huang,1 Hai Zhang,2 Ning Xu,1 Yang Liu,1 Xuan Liu,1 Yuanyuan Ye,1 Xinxin Zhang,1 Xiaoxi Xu,1 Yuxin Fan,1 Ziyue Zhang,1 Weiping J. Zhang,2 Shusen Wang,3 Wenli Feng,1 Peter Arvan,4 and Ming Liu1
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
Find articles by Liu, Y. in: PubMed | Google Scholar
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
Find articles by Liu, X. in: PubMed | Google Scholar
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
Find articles by Zhang, X. in: PubMed | Google Scholar
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
Find articles by Xu, X. in: PubMed | Google Scholar
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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Zhang, W.
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
Find articles by Wang, S. in: PubMed | Google Scholar
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
Find articles by Feng, W. in: PubMed | Google Scholar
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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Arvan, P.
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1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
2National Key Laboratory of Immunity and Inflammation, Department of Pathoph, Naval Medical University, Shanghai, China
3Human Islet Resource Center, Tianjin First Central Hospital, Tianjin, China
4Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, United States of America
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Liu, M.
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Published May 20, 2025 - More info
Copyright © 2025, Li et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)