Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • ASCI Milestone Awards
    • Video Abstracts
    • Conversations with Giants in Medicine
  • Reviews
    • View all reviews ...
    • Clinical innovation and scientific progress in GLP-1 medicine (Nov 2025)
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • ASCI Milestone Awards
  • Video Abstracts
  • Conversations with Giants in Medicine
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
How the JCI’s most-cited paper sparked the field of lipoprotein research
Michael S. Brown, Joseph L. Goldstein
Michael S. Brown, Joseph L. Goldstein
View: Text | PDF
100th Anniversary Viewpoints

How the JCI’s most-cited paper sparked the field of lipoprotein research

  • Text
  • PDF
Abstract

Authors

Michael S. Brown, Joseph L. Goldstein

×

Figure 1

The most-cited paper in the 100-year history of the JCI.

Options: View larger image (or click on image) Download as PowerPoint
The most-cited paper in the 100-year history of the JCI.
(A) A copy of t...
(A) A copy of the title page of the 1955 paper by Havel, Eder, and Bragdon, who described a method that used the ultracentrifuge to isolate plasma lipoproteins. (B) Annual citations from 1955 to 2023. The total number of citations is 8,913, according to data from the Web of Science. Google Scholar, whose citation counts are based on a larger set of publications, including non-peer-reviewed articles and book chapters, lists the total number of citations at 10,012). (C) The late Richard J. Havel, the lead author of the paper. The photograph is reproduced from Kane and Malloy (12). (D) Photographs of the luminal surface of aortas from a cholesterol-fed, wild-type mouse (top) and an Ldlr–/– mouse (bottom). The aortas were stained for lipid with Sudan IV. Mice from both genotypes were fed a diet containing 1.25% cholesterol, 7.5% cocoa butter, 7.5% casein, and 0.5% sodium cholate for 8 months and were sacrificed at 13 months. Photographs are reproduced from Ishibashi et al. (11).

Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts