Usage Information

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
Jean L. Chan, Kathleen Heist, Alex M. DePaoli, Johannes D. Veldhuis, Christos S. Mantzoros
Jean L. Chan, Kathleen Heist, Alex M. DePaoli, Johannes D. Veldhuis, Christos S. Mantzoros
Published May 1, 2003
Citation Information: J Clin Invest. 2003;111(9):1409-1421. doi:10.1172/JCI17490.
View: Text | PDF
Categories: Article Endocrinology

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

Abstract

To elucidate the role of leptin in regulating neuroendocrine and metabolic function during an acute fast, six to eight healthy, lean men were studied under four separate conditions: a baseline fed state and three 72-hour fasting studies with administration of either placebo, low-dose recombinant-methionyl human leptin (r-metHuLeptin), or replacement-dose r-metHuLeptin designed to maintain serum leptin at levels similar to those in the fed state. Replacement-dose r-metHuLeptin administered during fasting prevents the starvation-induced changes in the hypothalamic-pituitary-gonadal axis and, in part, the hypothalamic-pituitary-thyroid axis and IGF-1 binding capacity in serum. Thus, in normal men, the fall in leptin with fasting may be both necessary and sufficient for the physiologic adaptations of these axes, which require leptin levels above a certain threshold for activation. In contrast to findings in mice, fasting-induced changes in the hypothalamic-pituitary-adrenal, renin-aldosterone, and growth hormone–IGF-1 axes as well as fuel utilization may be independent of leptin in humans. The role of leptin in normalizing several starvation-induced neuroendocrine changes may have important implications for the pathophysiology and treatment of eating disorders and obesity.

Authors

Jean L. Chan, Kathleen Heist, Alex M. DePaoli, Johannes D. Veldhuis, Christos S. Mantzoros

×

This article was first published May 1, 2003. Usage data is cumulative from September 2016 through September 2017.

Usage JCI PMC
Text version 1,926 614
PDF 172 369
Figure 32 22
Table 97 0
Supplemental data 0 8
Citation downloads 27 0
Totals 2,254 1,013
Total Views 3,267
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement