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Research LetterIn-Press PreviewImmunologyInfectious disease Open Access | 10.1172/JCI171982

IRGM1 supports host defense against intracellular bacteria through suppression of type I interferon in mice

Prashant Rai,1 Martin Sharpe,1 Charan K. Ganta,2 Paul J. Baker,3 Katrin D. Mayer-Barber,3 Brian E. Fee,4 Gregory A. Taylor,4 and Michael B. Fessler1

1Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

2Comparative & Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

3Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, United States of America

4Department of Medicine, Duke University Medical Center, Durham, United States of America

Find articles by Rai, P. in: JCI | PubMed | Google Scholar |

1Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

2Comparative & Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

3Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, United States of America

4Department of Medicine, Duke University Medical Center, Durham, United States of America

Find articles by Sharpe, M. in: JCI | PubMed | Google Scholar

1Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

2Comparative & Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

3Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, United States of America

4Department of Medicine, Duke University Medical Center, Durham, United States of America

Find articles by Ganta, C. in: JCI | PubMed | Google Scholar

1Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

2Comparative & Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

3Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, United States of America

4Department of Medicine, Duke University Medical Center, Durham, United States of America

Find articles by Baker, P. in: JCI | PubMed | Google Scholar |

1Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

2Comparative & Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

3Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, United States of America

4Department of Medicine, Duke University Medical Center, Durham, United States of America

Find articles by Mayer-Barber, K. in: JCI | PubMed | Google Scholar |

1Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

2Comparative & Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

3Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, United States of America

4Department of Medicine, Duke University Medical Center, Durham, United States of America

Find articles by Fee, B. in: JCI | PubMed | Google Scholar

1Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

2Comparative & Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

3Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, United States of America

4Department of Medicine, Duke University Medical Center, Durham, United States of America

Find articles by Taylor, G. in: JCI | PubMed | Google Scholar |

1Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

2Comparative & Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, United States of America

3Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, United States of America

4Department of Medicine, Duke University Medical Center, Durham, United States of America

Find articles by Fessler, M. in: JCI | PubMed | Google Scholar |

Published September 12, 2023 - More info

J Clin Invest. https://doi.org/10.1172/JCI171982.
Copyright © 2023, Rai et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published September 12, 2023 - Version history
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