A monoclonal thyroid-stimulating antibody
Takao Ando, … , Yuji Nagayama, Terry F. Davies
Takao Ando, … , Yuji Nagayama, Terry F. Davies
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1667-1674. https://doi.org/10.1172/JCI16991.
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Article Autoimmunity

A monoclonal thyroid-stimulating antibody

Abstract

Research Article

Authors

Takao Ando, Rauf Latif, Alla Pritsker, Thomas Moran, Yuji Nagayama, Terry F. Davies

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Dose-response study of the blocking activity of MS-1. CHO-hTSHR cells we...
Dose-response study of the blocking activity of MS-1. CHO-hTSHR cells were stimulated with MS-1 at the indicated concentrations with or without 100 μU/ml of TSH. Since MS-1 is a TSHR-stimulating monoclonal antibody, the cAMP generated by MS-1 alone was subtracted from the cAMP generated by MS-1 plus TSH. Medium alone produced less than 50 fmol/well cAMP, and TSH (100 μU/ml) generated 2,000 fmol/well.