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Clinical MedicineIn-Press PreviewImmunology
Open Access | 
10.1172/JCI169496
KIR-HLA interactions extend human CD8+ T cell lifespan in vivo
Yan Zhang,1 Ada W.C. Yan,2 Lies Boelen,2 Linda Hadcocks,1 Arafa Salam,1 Daniel Padrosa Gispert,2 Loiza Spanos,1 Laura Mora Bitria,2 Neda Nemat-Gorgani,3 James A. Traherne,4 Chrissy H. Roberts,5 Danai A. Koftori,2 Graham P. Taylor,6 Daniel Forton,7 Paul J. Norman,8 Steven G.E. Marsh,9 Robert Busch,10 Derek Macallan,11 and Becca Asquith2
1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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1Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom
2Department of Infectious Disease, Imperial College London, London, United Kingdom
3Department of Structural Biology and Department of Microbiology and Immunol, Stanford University School of Medicine, Stanford, United States of America
4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
5Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
6Department of Infectious Disease, Imperial College of London, London, United Kingdom
7Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
8Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States of America
9Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
10School of Life and Health Sciences, University of Roehampton, London, United Kingdom
11Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom
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Published April 18, 2023 - More info
Copyright © 2023, Zhang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)