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ResearchIn-Press PreviewImmunologyOncology
Open Access | 10.1172/JCI166070
1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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1School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2BRC Advanced Cytometry Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
3BRC Translational Bioinformatics, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
4BRC Genomics Research Platform, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London, United Kingdom
5Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden
6Immunity & Cancer Laboratory, Francis Crick Institute, London, United Kingdom
7Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
8Department of Haematology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
95th Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
10Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
11Department of Translational Medicine, Bristol-Myers Squibb, Summit, United States of America
12Department of Translational Medicine, Bristol Myers Squibb, Summit, United States of America
13Department of Oncology Discovery, Roche Innovation Center Zurich, Zurich, Switzerland
14MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
15Division of Hematology, Medical University Graz, Graz, Austria
16School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
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Published May 23, 2023 - More info
Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has highlighted the clinical relevance of lymph node (LN) fibroblast and tumor-infiltrating lymphocyte (TIL) signatures within the tumor microenvironment (TME). However, the immunomodulatory role of fibroblasts in lymphoma remains unclear. Here, by studying human and mouse DLBCL-LNs, we identify the presence of an aberrantly remodeled fibroblastic reticular cell (FRC) network, expressing elevated fibroblast activated protein (FAP). RNA-sequencing analyses reveal that exposure to DLBCL reprograms key immunoregulatory pathways in FRCs, including a switch from homeostatic to inflammatory chemokine expression and elevated antigen presentation molecules. Functional assays show that DLBCL-activated FRCs (DLBCL-FRCs) hinder optimal TIL and chimeric antigen receptor T cell (CAR-T) migration. Moreover, DLBCL-FRCs inhibited CD8+ TIL cytotoxicity in an antigen-specific manner. Notably, the interrogation of patient LNs with imaging mass cytometry identified distinct environments differing in their CD8+ TIL-FRC composition and spatial organization that associated with survival outcomes. We further demonstrate the potential to target inhibitory FRCs to rejuvenate interacting TILs. Co-treating organotypic cultures with FAP-targeted immunostimulatory drugs and a bispecific antibody (glofitamab) augmented anti-lymphoma TIL cytotoxicity. Together, our study reveals an immunosuppressive role of FRCs in DLBCL, with implications for immune evasion, disease pathogenesis and optimizing immunotherapy for patients.