Hiroyasu Tsukaguchi, Akulapalli Sudhakar, Tu Cam Le, Trang Nguyen, Jun Yao, Joshua A. Schwimmer, Asher D. Schachter, Esteban Poch, Patricia F. Abreu, Gerald B. Appel, Aparecido B. Pereira, Raghu Kalluri, Martin R. Pollak
Haplotype analysis for 1q25 markers surrounding the NPHS2 gene. Haplotypes of chromosomes bearing the R229Q-encoding mutations are shown. (a) The genomic context of the markers used. (b) Portions of the haplotypes that are totally conserved (dark gray) and partially shared (light gray) are indicated. The orders and intervals of the frame markers are determined based on Genemap ’99 (www.ncbi.nlm.nih.gov/genemap), the Sanger Center chromosome database. The markers CA126, CA1419, and D1S3760 are derived from the BACs harboring NPHS2 and two neighboring genes SOAT1 (sterol-O-acetyltransferase) and KIAA0475. Cent., centromere; Tel., telomere.