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Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils
Andrei L. Kindzelskii, … , Roberto Romero, Howard R. Petty
Andrei L. Kindzelskii, … , Roberto Romero, Howard R. Petty
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1801-1811. https://doi.org/10.1172/JCI15973.
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Article Cell biology

Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils

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Abstract

Research Article

Authors

Andrei L. Kindzelskii, Ji-Biao Huang, Tinnakorn Chaiworapongsa, Ryan M. Fahmy, Yeon Mee Kim, Roberto Romero, Howard R. Petty

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Figure 8

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Rates of ROM release by neutrophils from nonpregnant (a and c) and pregn...
Rates of ROM release by neutrophils from nonpregnant (a and c) and pregnant subjects (b and d). ROM release was measured during cell migration through a matrix containing H2TMRos (35). For all panels, the cells are adherent and traces labeled 1–9 are: 1, untreated; 2, LPS; 3, IFN-γ; 4, 6-AN; 5, IFN-γ plus LPS; 6, LPS plus 6-AN; 7, colchicine; 8, LPS plus colchicine; and 9, LPS plus colchicine and 6-AN. The greatest rates of ROM release from pregnancy neutrophils require the addition of colchicine. See Table 1 for further quantitative results. Vertical bar = 10,000 counts.

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