Advertisement
Clinical MedicineIn-Press PreviewCOVID-19Immunology
Open Access | 10.1172/JCI159500
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by
Qui, M.
in:
JCI
|
PubMed
|
Google Scholar
|
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by
Le Bert, N.
in:
JCI
|
PubMed
|
Google Scholar
|
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by Chan, W. in: JCI | PubMed | Google Scholar
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by
Tan, M.
in:
JCI
|
PubMed
|
Google Scholar
|
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by
Hang, S.
in:
JCI
|
PubMed
|
Google Scholar
|
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by Hariharaputran, S. in: JCI | PubMed | Google Scholar
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by Sim, J. in: JCI | PubMed | Google Scholar
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by
Low, J.
in:
JCI
|
PubMed
|
Google Scholar
|
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by Ng, W. in: JCI | PubMed | Google Scholar
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by Wan, W. in: JCI | PubMed | Google Scholar
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by
Ang, T.
in:
JCI
|
PubMed
|
Google Scholar
|
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by
Bertoletti, A.
in:
JCI
|
PubMed
|
Google Scholar
|
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
2Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore
3Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore
4Department of Microbiology, Singapore General Hospital, Singapore, Singapore
5Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore
Find articles by Salazar, E. in: JCI | PubMed | Google Scholar
Published May 10, 2022 - More info
BACKGROUND. Patients undergoing immune-modifying therapies demonstrate a reduced humoral response after COVID-19 vaccination, but we lack a proper evaluation of the impact of such therapies on vaccine-induced T cell responses.
METHODS. We longitudinally characterized humoral and Spike-specific T cell responses in inflammatory bowel disease (IBD) patients who are on antimetabolite therapy (azathioprine or methotrexate), TNF inhibitors and/or other biologic treatment (anti-integrin or anti-p40) for up to 6 months after completing two-dose COVID-19 mRNA vaccination.
RESULTS. We demonstrated that a Spike-specific T cell response is not only induced in treated IBD patients at levels similar to healthy individuals, but also sustained at higher magnitude for up to 6 months after vaccination, particularly in those treated with TNF inhibitor therapy. Furthermore, the Spike-specific T cell response in these patients is mainly preserved against mutations present in SARS-CoV-2 B.1.1.529 (Omicron) and characterized by a Th1/IL-10 cytokine profile.
CONCLUSION. Despite the humoral response defects, patients under immune-modifying therapies demonstrated a favorable profile of vaccine-induced T cell responses that might still provide a layer of COVID-19 protection.
FUNDING. This study was funded by the National Centre for Infectious Diseases NCID Catalyst Grant (FY2021ES) and the National Research Fund Competitive Research Programme (NRF-CRP25-2020-0003). The funders played no role in the design, conduct, or reporting of this study.