Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice
Hong Xiao, Peter Heeringa, Peiqi Hu, Zhi Liu, Minglang Zhao, Yasuaki Aratani, Nobuyo Maeda, Ronald J. Falk, J. Charles Jennette
Hong Xiao, Peter Heeringa, Peiqi Hu, Zhi Liu, Minglang Zhao, Yasuaki Aratani, Nobuyo Maeda, Ronald J. Falk, J. Charles Jennette
View: Text | PDF
Article Immunology

Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice

Abstract

Research Article

Authors

Hong Xiao, Peter Heeringa, Peiqi Hu, Zhi Liu, Minglang Zhao, Yasuaki Aratani, Nobuyo Maeda, Ronald J. Falk, J. Charles Jennette

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
Anti-MPO antibody ELISA titers in Rag2–/– mice that received 1 × 108 ant...
Anti-MPO antibody ELISA titers in Rag2–/– mice that received 1 × 108 anti-MPO splenocytes (closed diamonds), 5 × 107 anti-MPO splenocytes (filled squares), 1 × 107 anti-MPO splenocytes (filled triangles), 1 × 108 anti-BSA splenocytes (open triangles), or 1 × 108 splenocytes from nonimmunized mice (open circles). Mice that received 5 × 107 or 1 × 107 anti-BSA splenocytes had no values above 15 (data not shown).