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Open Access | 10.1172/JCI157415
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Find articles by Levitt, L. in: JCI | PubMed | Google Scholar
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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Lilleri, D.
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Find articles by Vainer, G. in: JCI | PubMed | Google Scholar
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Find articles by Furione, M. in: JCI | PubMed | Google Scholar
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Find articles by Oiknine-Djian, E. in: JCI | PubMed | Google Scholar
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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Kupervaser, M.
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Find articles by Nevo, Y. in: JCI | PubMed | Google Scholar
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Find articles by Elgavish, S. in: JCI | PubMed | Google Scholar
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Find articles by Yassour, M. in: JCI | PubMed | Google Scholar
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Find articles by Zavattoni, M. in: JCI | PubMed | Google Scholar
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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Geal-Dor, M.
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Find articles by Zakay-Rones, Z. in: JCI | PubMed | Google Scholar
1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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1Clinical Virology Unit, The Hebrew University of Jerusalem, Jerusalem, Israel
2Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
3Department of Microbiology and Virology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
4Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
5Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
6Maccabi Healthcare Services, Rehovot, Israel
7Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
8Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
9Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem, Israel
10School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
11Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
12Department of Speech and Hearing, Hadassah Hebrew University Medical Center, Jerusalem, Israel
13Department of Biochemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
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Published April 19, 2022 - More info
BACKGROUND. Cytomegalovirus (CMV) is the most common intrauterine infection, leading to infant brain damage. Prognostic assessment of CMV-infected fetuses has remained an ongoing challenge in prenatal care, in the absence of established prenatal biomarkers of congenital CMV (cCMV) infection severity. We aimed to identify prognostic biomarkers of cCMV-related fetal brain injury.
METHODS. Global proteome analysis was performed in mid-gestation amniotic fluid samples, comparing fetuses with severe cCMV to asymptomatic CMV-infected fetuses. The levels of selected differentially-excreted proteins were further determined by specific immunoassays.
RESULTS. Employing unbiased proteome analysis in a discovery cohort, we identified amniotic fluid proteins related to inflammation and neurological disease pathways, which demonstrated distinct abundance in fetuses with severe cCMV. Amniotic fluid levels of two of these proteins - the immunomodulatory proteins chemerin and galectin-3-binding-protein - were highly predictive of the severity of cCMV in an independent validation cohort, differentiating between fetuses with severe (N=17) and asymptomatic (N=26) cCMV, with 100-93.8% positive predictive value, and 92.9-92.6% negative predictive value (for chemerin - galectin-3-binding-protein, respectively).
CONCLUSION. Analysis of chemerin and galectin-3-binding-protein in mid-gestation amniotic fluids could be employed in the clinical setting to profoundly improve the prognostic assessment of CMV-infected fetuses.
TRIAL REGISTRATION. NA
FUNDING. Israel Science Foundation; Research Fund - Hadassah Medical Organization.