T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase
Mark W. Musch, … , Eugene B. Chang, Terrence A. Barrett
Mark W. Musch, … , Eugene B. Chang, Terrence A. Barrett
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1739-1747. https://doi.org/10.1172/JCI15695.
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Article Inflammation

T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase

Abstract

Research Article

Authors

Mark W. Musch, Lane L. Clarke, Daniel Mamah, Lara R. Gawenis, Zheng Zhang, William Ellsworth, David Shalowitz, Navdha Mittal, Petros Efthimiou, Ziad Alnadjim, Steve D. Hurst, Eugene B. Chang, Terrence A. Barrett

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Figure 2

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Effect of TNF or IFN-γ on wt/l ratios. (a) Mice were injected with contr...
Effect of TNF or IFN-γ on wt/l ratios. (a) Mice were injected with control antibody, anti-CD3 mAb, TNF, or IFN-γ. Jejunal wt/l ratios were measured at 3 hours. Values are means ± SE for six determinations. (b) Dose-dependence of TNF effect. Mice were injected with varying amounts of TNF, and jejunal wt/l ratios were measured at 3 hours. Values are means ± SE for six determinations in each group or each TNF dose. *P < 0.05, **P < 0.01 compared with control antibody in a and 0 TNF in b by ANOVA.