Neutrophil-independent mechanisms of caspase-1– and IL-18–mediated ischemic acute tubular necrosis in mice
Vyacheslav Y. Melnikov, Sarah Faubel, Britta Siegmund, M. Scott Lucia, Danica Ljubanovic, Charles L. Edelstein
Vyacheslav Y. Melnikov, Sarah Faubel, Britta Siegmund, M. Scott Lucia, Danica Ljubanovic, Charles L. Edelstein
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Article Cell biology

Neutrophil-independent mechanisms of caspase-1– and IL-18–mediated ischemic acute tubular necrosis in mice

Abstract

Research Article

Authors

Vyacheslav Y. Melnikov, Sarah Faubel, Britta Siegmund, M. Scott Lucia, Danica Ljubanovic, Charles L. Edelstein

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Mice treated with OPH-001 are histologically protected against ischemic ...
Mice treated with OPH-001 are histologically protected against ischemic ARF. Mice treated with OPH-001 before induction of ischemia had a significant reduction in ATN score compared with vehicle-treated mice. *P < 0.001 vs. sham; **P < 0.001 vs. vehicle-treated ARF; n = 6.