Mice treated with OPH-001 are functionally protected against ischemic ARF. In vehicle-treated mice with ischemic ARF, serum creatinine was significantly increased at 24 hours and 48 hours of reperfusion compared with sham-operated controls. In mice treated with OPH-001 before induction of ischemic ARF, the serum creatinine was normalized at 24 hours and 48 hours of reperfu-sion compared with sham-operated controls. *P < 0.01 vs. sham; **P < 0.01 vs. vehicle-treated ARF, NS vs. sham; n = 8 at 24 hours. ⁺P < 0.05 vs. sham; ⁺⁺P < 0.05 vs. vehicle-treated ARF, NS vs. sham; n = 6 at 48 and 72 hours. Veh, vehicle.