Total ACTH content (ng/well; mean ± SEM) measured during basal conditions in the NCR-normoxemic (NCR-NX) and CR-NX groups and in the NCR-hypoxemic (NCR-HX) and CR-HX groups after vehicle (white bars) or C-TOX treatment (black bars). Light gray, hypoxemia; medium gray, maternal carunclectomy; dark gray, hypoxemia and maternal carunclectomy. *P < 0.05, vehicle vs. C-TOX groups.