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Open Access | 
10.1172/JCI154118
The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia
Nils Korte,1 Zeki Ilkan,2 Claire L. Pearson,2 Thomas Pfeiffer,1 Prabhav Singhal,1 Jason R. Rock,3 Huma Sethi,4 Dipender Gill,5 David Attwell,1 and Paolo Tammaro2
1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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Singhal, P.
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1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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Attwell, D.
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1Department of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom
2Department of Pharmacology, University of Oxford, Oxford, United Kingdom
3Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, United States of America
4Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
5Department of Biostatistics and Epidemiology, Imperial College London, London, United Kingdom
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Tammaro, P.
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Published March 22, 2022 - More info
Copyright © 2022, Korte et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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ISSN: 0021-9738 (print), 1558-8238 (online)