Christian F. Krieglstein, Wolfgang H. Cerwinka, Andrew G. Sprague, F. Stephen Laroux, Matthew B. Grisham, Victor E. Koteliansky, Norbert Senninger, D. Neil Granger, Antonin R. de Fougerolles
Blockade of α1 inhibits cytokine mRNA expression in DSS-treated murine colons. Levels of TNF-α, IFN-γ, IL-1β, IL-12, and IL-10 mRNA expression were measured in colons from WT or α1-deficient mice treated for 7 days with DSS. DSS-treated WT mice received either no mAb, isotype control mAb, or anti-α1 mAb. For quantitation, cytokine values are expressed as fold increase over the mean values obtained for healthy control colon tissue. *P < 0.05, anti-α1 mAb vs. isotype mAb and α1–/– vs. WT, respectively. #P < 0.05 vs. WT + H2O. Data represent mean ± SEM. ctrl, control.