Effect of mTNF and NGR-mTNF on tumor growth and body weight of animals bearing RMA-T lymphomas. Animals bearing RMA-T tumors (five mice per group) were treated intraperitoneally with NGR-mTNF or mTNF at day 12 after tumor implantation (a) or at days 10, 11, and 12 (b), in two separate experiments (Exp. 1 and Exp. 2). Tumor volumes in Exp. 1 (a) and Exp. 2 (b) and animal body weight in Exp. 1 (c) 1–4 days after treatment are shown. The arrowheads in c indicate the time of treatment.