Department of Microbiology and Immunology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA.
Address correspondence to: Tonya J. Webb, 685 W. Baltimore St., Baltimore, Maryland 21201, USA. Phone: 410.706.4109; Email: email@example.com.
Published September 15, 2021 - More info
Natural killer (NK) cells play an important role in host defense against viral infections and malignancy, and their role for regulating other components of the antiviral response is being investigated. In this issue of the JCI, Ali et al. examine the mechanisms by which NK cells migrate into the white pulp and mediate suppression of virus-specific T cells. Herein, the authors show that an acute lymphocytic choriomeningitis virus (LCMV) infection induced a potent type I IFN (IFN-I) response that resulted in the expression of chemokine receptor CXCR3 ligands and permitted NK cell trafficking to T cell zones. Collectively, these findings have broad implications for vaccination strategies and warrant further investigation into the transcriptomic profiles of these regulatory NK cells.
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