Published June 1, 2021 - More info
Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during ART. A large number of studies conducted during the past 20 years have shown that HIV persists in a small pool of cells harboring integrated and replication-competent viral genomes. The majority of these cells do not produce viral particles and constitute what is referred to as the latent reservoir of HIV infection. Therefore, although HIV is not considered as a typical latent virus, it can establish a state of nonproductive infection under rare circumstances, particularly in memory CD4+ T cells, which represent the main barrier to HIV eradication. While it was originally thought that the pool of latently infected cells was largely composed of cells harboring transcriptionally silent genomes, recent evidence indicates that several blocks contribute to the nonproductive state of these cells. Here, we describe the virological and immunological factors that play a role in the establishment and persistence of the pool of latently infected cells and review the current approaches aimed at eliminating the latent HIV reservoir.
Caroline Dufour, Pierre Gantner, Rémi Fromentin, Nicolas Chomont
Original citation: J Clin Invest. 2020;130(7):3381–3390. https://doi.org/10.1172/JCI136227
Citation for this corrigendum: J Clin Invest. 2021;131(11):e151380. https://doi.org/10.1172/JCI151380
The description of the effect of polypyrimidine tract–binding protein (PTB) on HIV RNA export was incorrect in the section Molecular mechanisms of HIV latency and in Figure 3.
The correct sentence is below.
Furthermore, viral RNAs accumulate in the nucleus of latently infected cells, and this defect in RNA export can be reverted by overexpressing the polypyrimidine tract–binding protein (PTB) in resting cells (39).
The text and Figure 3 have been updated in the HTML version and PDF with the correct information.
The authors regret the error.