Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome
Duarte C. Barral, José S. Ramalho, Ross Anders, Alistair N. Hume, Holly J. Knapton, Tanya Tolmachova, Lucy M. Collinson, David Goulding, Kalwant S. Authi, Miguel C. Seabra
Duarte C. Barral, José S. Ramalho, Ross Anders, Alistair N. Hume, Holly J. Knapton, Tanya Tolmachova, Lucy M. Collinson, David Goulding, Kalwant S. Authi, Miguel C. Seabra
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Article Genetics

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome

Abstract

Research Article

Authors

Duarte C. Barral, José S. Ramalho, Ross Anders, Alistair N. Hume, Holly J. Knapton, Tanya Tolmachova, Lucy M. Collinson, David Goulding, Kalwant S. Authi, Miguel C. Seabra

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Figure 6

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Immuno-EM of wild-type platelets. Platelets from C3H/He+/+ mice were pro...
Immuno-EM of wild-type platelets. Platelets from C3H/He+/+ mice were processed for immuno-EM as described in Methods. Affinity-purified polyclonal anti-Rab27a Ab N688 was used to probe for Rab27a (a) and affinity-purified polyclonal anti-Rab27b S086 to probe for Rab27b (b). The labeling was found mainly in dense granules (arrowheads). Some labeling was also detected in α-granules (arrows). Bars, 100 nm.