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Usage Information

Targeting memory T cell metabolism to improve immunity
Mauro Corrado, Erika L. Pearce
Mauro Corrado, Erika L. Pearce
Published January 4, 2022
Citation Information: J Clin Invest. 2022;132(1):e148546. https://doi.org/10.1172/JCI148546.
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Review Series

Targeting memory T cell metabolism to improve immunity

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Abstract

Vaccination affords protection from disease by activating pathogen-specific immune cells and facilitating the development of persistent immunologic memory toward the vaccine-specific pathogen. Current vaccine regimens are often based on the efficiency of the acute immune response, and not necessarily on the generation of memory cells, in part because the mechanisms underlying the development of efficient immune memory remain incompletely understood. This Review describes recent advances in defining memory T cell metabolism and how metabolism of these cells might be altered in patients affected by mitochondrial diseases or metabolic syndrome, who show higher susceptibility to recurrent infections and higher rates of vaccine failure. It discusses how this new understanding could add to the way we think about immunologic memory, vaccine development, and cancer immunotherapy.

Authors

Mauro Corrado, Erika L. Pearce

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 4,692 1,073
PDF 517 237
Figure 1,083 2
Table 81 0
Citation downloads 123 0
Totals 6,496 1,312
Total Views 7,808
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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