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ResearchIn-Press PreviewCOVID-19Immunology Free access | 10.1172/JCI144554
1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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Esteve-Sole, A.
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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Anton, J.
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
2Institut de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
14Cardiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
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1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
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3Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
4Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain
5Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
11IrsiCaixa, AIDS Research Institute, Badalona, Spain
12Department of Immunology-CDB, HCB-IDIBAPS, Barcelona, Spain
13Statistical Department, Fundació Sant Joan de Déu, Barcelona, Spain
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6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
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6Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America
7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
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7Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain
8Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
9Molecular Biology Core, CDB, HCB-IDIBAPS, Barcelona, Spain
10Microbiology Department, CDB, HCB, Barcelona, Spain
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Published January 26, 2021 - More info
Multisystem inflammatory syndrome associated with the SARS-CoV-2 pandemic has recently been described in children (MIS-C), partially overlapping with Kawasaki disease (KD). We hypothesized that: 1) MIS-C and pre-pandemic KD cytokine profiles may be unique and justify the clinical differences observed; 2) SARS-CoV-2-specific immune complexes (IC) may explain the immunopathology of MIS-C. Seventy-four children were included: 14 MIS-C; 9 patients with positive SARS-CoV-2-PCR without MIS-C (COVID); 14 pre-pandemic KD and 37 healthy controls (HC). Thirty-four circulating cytokines were quantified in pre-treatment serum or plasma samples and the presence of circulating SARS-CoV-2 IC was evaluated in MIS-C patients. Compared to HC, MIS-C and KD groups showed most cytokines to be significantly elevated, with IFN-γ-induced response markers (including IFN-γ, IL-18, IP-10) and inflammatory monocytes activation markers (including MCP-1, IL-1α, IL-1RA) being the main triggers of inflammation. With linear discriminant analysis, MIS-C and KD profiles overlapped; however, a subgroup of MIS-C patients (MIS-Cplus) differentiated from the remaining MIS-C patients in IFN-γ, IL-18, GM-CSF, RANTES, IP-10, IL-1α and SDF-1 and incipient signs of macrophagic activation syndrome. Circulating SARS-CoV-2-IC were not detected in MIS-C patients. Our findings suggest a major role of IFN-γ in the pathogenesis of MIS-C, which may be relevant for therapeutic management.