[HTML][HTML] Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital

AL Garcia-Basteiro, G Moncunill, M Tortajada… - Nature …, 2020 - nature.com
AL Garcia-Basteiro, G Moncunill, M Tortajada, M Vidal, C Guinovart, A Jimenez, R Santano
Nature communications, 2020nature.com
Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from
patients or other fellow HCW. This study aims at estimating the seroprevalence against
SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578
participants recruited from 28 March to 9 April 2020, 54 (9.3%, 95% CI: 7.1–12.0) were
seropositive for IgM and/or IgG and/or IgA against SARS-CoV-2. The cumulative prevalence
of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) was …
Abstract
Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%, 95% CI: 7.1–12.0) were seropositive for IgM and/or IgG and/or IgA against SARS-CoV-2. The cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) was 11.2% (65/578, 95% CI: 8.8–14.1). Among those with evidence of past or current infection, 40.0% (26/65) had not been previously diagnosed with COVID-19. Here we report a relatively low seroprevalence of antibodies among HCW at the peak of the COVID-19 epidemic in Spain. A large proportion of HCW with past or present infection had not been previously diagnosed with COVID-19, which calls for active periodic rRT-PCR testing in hospital settings.
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