Neutrophil dynamics in the tumor microenvironment
Amanda J. McFarlane,1 Frédéric Fercoq,1 Seth B. Coffelt,1,2 and Leo M. Carlin1,2
1Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
2Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
Address correspondence to: Seth B. Coffelt or Leo M. Carlin, Cancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom. Phone: 44.141.330.2864; Email: seth.coffelt@glasgow.ac.uk (SBC). Phone: 44.141.330.6336; Email: leo.carlin@glasgow.ac.uk (LMC).
Authorship note: AJM and FF are co–first authors.
Find articles by McFarlane, A. in: JCI | PubMed | Google Scholar
1Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
2Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
Address correspondence to: Seth B. Coffelt or Leo M. Carlin, Cancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom. Phone: 44.141.330.2864; Email: seth.coffelt@glasgow.ac.uk (SBC). Phone: 44.141.330.6336; Email: leo.carlin@glasgow.ac.uk (LMC).
Authorship note: AJM and FF are co–first authors.
Find articles by Fercoq, F. in: JCI | PubMed | Google Scholar
1Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
2Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
Address correspondence to: Seth B. Coffelt or Leo M. Carlin, Cancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom. Phone: 44.141.330.2864; Email: seth.coffelt@glasgow.ac.uk (SBC). Phone: 44.141.330.6336; Email: leo.carlin@glasgow.ac.uk (LMC).
Authorship note: AJM and FF are co–first authors.
Find articles by
Coffelt, S.
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PubMed
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1Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
2Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
Address correspondence to: Seth B. Coffelt or Leo M. Carlin, Cancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom. Phone: 44.141.330.2864; Email: seth.coffelt@glasgow.ac.uk (SBC). Phone: 44.141.330.6336; Email: leo.carlin@glasgow.ac.uk (LMC).
Authorship note: AJM and FF are co–first authors.
Find articles by Carlin, L. in: JCI | PubMed | Google Scholar
Published March 15, 2021 - More info
J Clin Invest. 2021;131(6):e143759. https://doi.org/10.1172/JCI143759.
© 2021 American Society for Clinical Investigation
The tumor microenvironment profoundly influences the behavior of recruited leukocytes and tissue-resident immune cells. These immune cells, which inherently have environmentally driven plasticity necessary for their roles in tissue homeostasis, dynamically interact with tumor cells and the tumor stroma and play critical roles in determining the course of disease. Among these immune cells, neutrophils were once considered much more static within the tumor microenvironment; however, some of these earlier assumptions were the product of the notorious difficulty in manipulating neutrophils in vitro. Technological advances that allow us to study neutrophils in context are now revealing the true roles of neutrophils in the tumor microenvironment. Here we discuss recent data generated by some of these tools and how these data might be synthesized into more elegant ways of targeting these powerful and abundant effector immune cells in the clinic.
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