Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Corrigendum Free access | 10.1172/JCI14327C1

Origin of endothelial progenitors in human postnatal bone marrow

Morayma Reyes, Arkadiusz Dudek, Balkrishna Jahagirdar, Lisa Koodie, Paul H. Marker, and Catherine M. Verfaillie

Find articles by Reyes, M. in: PubMed | Google Scholar

Find articles by Dudek, A. in: PubMed | Google Scholar

Find articles by Jahagirdar, B. in: PubMed | Google Scholar

Find articles by Koodie, L. in: PubMed | Google Scholar

Find articles by Marker, P. in: PubMed | Google Scholar

Find articles by Verfaillie, C. in: PubMed | Google Scholar

Published November 3, 2008 - More info

Published in Volume 118, Issue 11 on November 3, 2008
J Clin Invest. 2008;118(11):3813–3813. https://doi.org/10.1172/JCI14327C1.
© 2008 The American Society for Clinical Investigation
Published November 3, 2008 - Version history
View PDF

Related article:

Origin of endothelial progenitors in human postnatal bone marrow
Morayma Reyes, … , Paul H. Marker, Catherine M. Verfaillie
Morayma Reyes, … , Paul H. Marker, Catherine M. Verfaillie
Article

Origin of endothelial progenitors in human postnatal bone marrow

  • Text
  • PDF
Abstract

This study demonstrates that a CD34–, vascular endothelial cadherin– (VE-cadherin–), AC133+, and fetal liver kinase+ (Flk1+) multipotent adult progenitor cell (MAPC) that copurifies with mesenchymal stem cells from postnatal human bone marrow (BM) is a progenitor for angioblasts. In vitro, MAPCs cultured with VEGF differentiate into CD34+, VE-cadherin+, Flk1+ cells — a phenotype that would be expected for angioblasts. They subsequently differentiate into cells that express endothelial markers, function in vitro as mature endothelial cells, and contribute to neoangiogenesis in vivo during tumor angiogenesis and wound healing. This in vitro model of preangioblast-to-endothelium differentiation should prove very useful in studying commitment to the angioblast and beyond. In vivo, MAPCs can differentiate in response to local cues into endothelial cells that contribute to neoangiogenesis in tumors. Because MAPCs can be expanded in culture without obvious senescence for more than 80 population doublings, they may be an important source of endothelial cells for cellular pro- or anti-angiogenic therapies.

Authors

Morayma Reyes, Arkadiusz Dudek, Balkrishna Jahagirdar, Lisa Koodie, Paul H. Marker, Catherine M. Verfaillie

×

Original citation: J. Clin. Invest.109:337–346 (2002). doi:10.1172/JCI14327.

Citation for this corrigendum: J. Clin. Invest.118:3813 (2008). doi:10.1172/JCI14327C1.

During the preparation of the manuscript, the FACS plot for β2-microglobulin was erroneously duplicated to also represent CD62P in Figure 1B. The legend to Figure 5C was also affected by the error. The correct Figure 1B and legend to Figure 5C appear below.

Figure 1B

Figure 5C

IL-1α induces expression of HLA-DR, a type of HLA class II antigen, and increases expression of adhesion receptors. MAPC-derived endothelial cells were incubated with or without 75 ng/ml IL-1α in serum-free medium for 24 hours. Cells were stained with Ab’s against HLA class I, HLA class II, β2-microglobulin, vWF, CD31, VCAM, CD62E, CD62P, or control Ab’s and analyzed using FACS. Plots show isotype control IgG staining profile (thin line) versus specific Ab staining profile (thick line). Representative example of three experiments from three donors. Numbers above each plot show MFI for the control IgG staining and the specific Ab staining. Nl, normal; IL-1, induced populations. Note that the histograms for normal β2-microglobulin, HLA class I, and HLA-DR are the same histograms presented in Figure 1B.

The authors regret the error.

Version history
  • Version 1 (November 3, 2008): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts