Advertisement
ResearchIn-Press PreviewOncology Free access | 10.1172/JCI141566
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Matthijssens, F.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Sharma, N. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Nysus, M. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Nickl, C. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Kang, H.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Perez, D. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Lintermans, B. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Van Loocke, W. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Roels, J.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Peirs, S.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Demoen, L.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Pieters, T. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Reunes, L. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Lammens, T. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
De Moerloose, B.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Van Nieuwerburgh, F.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Deforce, D.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Cheung, L.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Kotecha, R.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Risseeuw, M.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Van Calenbergh, S.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Takarada, T.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Yoneda, Y.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
van Delft, F.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Lock, R. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Merkley, S. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Chigaev, A.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Sklar, L. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Mullighan, C.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Loh, M.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Winter, S.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Hunger, S.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by Goossens, S. in: JCI | PubMed | Google Scholar
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Castillo, E.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Ornatowski, W.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Van Vlierberghe, P.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
2Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, United States of America
3Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, United States of America
4Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
5Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
6Telethon Kids Cancer Centre, University of Western Australia, Perth, Australia
7Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium
8Department of Regenerative Science, Okayama University Graduate School of Medicine, Okayama, Japan
9Department of Pharmacology, Osaka University Graduate School of Dentistry, Kanazawa, Japan
10Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle, United Kingdom
11Children's Cancer Institute, University of New South Wales, Sydney, Australia
12Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, United States of America
13Comprehensive Cancer Center, University of New Mexico, Albuquerque, United States of America
14Department of Pathology, St. Jude Children`s Research Hospital, Memphis, United States of America
15Department of Pediatrics, UCSF, San Francisco, United States of America
16Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, United States of America
17Department of Pediatrics and the Center for Childhood Cancer Research, University of Pennsylvania, Philadelphia, United States of America
18Department of Medicine, University of Arizona, Arizona, United States of America
19Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, United States of America
Find articles by
Matlawska-Wasowska, K.
in:
JCI
|
PubMed
|
Google Scholar
|
Published February 8, 2021 - More info
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared to B-cell ALL. Here, we showed that Runt-related transcription factor 2, RUNX2 was upregulated in high-risk T-ALL with KMT2A rearrangements (KMT2A-R) or an immature immunophenotype. In KMT2A-R cells, we identified RUNX2 as a direct target of the KMT2A chimeras, where it reciprocally bound the KMT2A promoter, establishing a regulatory feed-forward mechanism. Notably, RUNX2 was required for survival of immature and KMT2A-R T-ALL cells in vitro and in vivo. We reported direct transcriptional regulation of CXCR4 signaling by RUNX2, thereby promoting chemotaxis, adhesion and homing to medullary and extramedullary sites. RUNX2 enabled these energy-demanding processes by increasing metabolic activity in T-ALL cells through positive regulation of both glycolysis and oxidative phosphorylation. Concurrently, RUNX2 upregulation increased mitochondrial dynamics and biogenesis in T-ALL cells. Finally, as a proof of concept, we demonstrated that immature and KMT2A-R T-ALL cells were vulnerable to pharmacological targeting of the interaction between RUNX2 and its co-factor CBFβ. In conclusion, we showed that RUNX2 acts as a dependency factor in high-risk subtypes of human T-ALL through concomitant regulation of tumour metabolism and leukemic cell migration.