[HTML][HTML] Phosphorylation of β-catenin by AKT promotes β-catenin transcriptional activity
D Fang, D Hawke, Y Zheng, Y Xia… - Journal of Biological …, 2007 - ASBMB
Increased transcriptional activity of β-catenin resulting from Wnt/Wingless-dependent or-
independent signaling has been detected in many types of human cancer, but the
underlying mechanism of Wnt-independent regulation is poorly understood. We have
demonstrated that AKT, which is activated downstream from epidermal growth factor
receptor signaling, phosphorylates β-catenin at Ser 552 in vitro and in vivo. AKT-mediated
phosphorylation of β-catenin causes its disassociation from cell-cell contacts and …
independent signaling has been detected in many types of human cancer, but the
underlying mechanism of Wnt-independent regulation is poorly understood. We have
demonstrated that AKT, which is activated downstream from epidermal growth factor
receptor signaling, phosphorylates β-catenin at Ser 552 in vitro and in vivo. AKT-mediated
phosphorylation of β-catenin causes its disassociation from cell-cell contacts and …