HIV Dynamics and Replication Program, National Cancer Institute (NCI), NIH, Ft. Detrick, Maryland, USA.
Address correspondence to: Frank Maldarelli, HIV Dynamics and Replication Program, NCI, NIH, 1050 Boyles St., Fort Detrick, Frederick, Maryland 21702, USA. Phone: 301.846.5611; Email: firstname.lastname@example.org.
First published February 24, 2020 - More info
Currently, the incidence of HIV infection exceeds the death rate from HIV, and as a result, the prevalence of individuals living with the infection continues to increase. A critical limitation preventing the development of curative strategies is the lack of knowledge regarding mechanisms that allow HIV-infected cells to persist in individuals during combination antiviral therapy (ART). In this issue of the JCI, Chaillon and coworkers assessed HIV-infected cells from various anatomic compartments obtained through a rapid autopsy program of individuals undergoing long-term ART. This study, made possible with strong community collaboration, provides new insights on the potential locations of reservoirs of HIV-infected cells that persist during therapy.
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