CD8+ T cells and human cerebral malaria: a shifting episteme
Laurent Rénia,1 Georges E.R. Grau,2 and Samuel C. Wassmer3
1Singapore Immunology Network, Agency for Science, Technology, and Research (A*STAR), Singapore.
2 Vascular Immunology Unit, Department of Pathology, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
3Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Address correspondence to: Samuel C. Wassmer, London School of Hygiene & Tropical Medicine, Department of Infection Biology, Keppel Street, London WC1E 7HT United Kingdom. Phone: 44.20.7612.7888; Email: sam.wassmer@lshtm.ac.uk.
Find articles by
Rénia, L.
in:
JCI
|
PubMed
|
Google Scholar
|
1Singapore Immunology Network, Agency for Science, Technology, and Research (A*STAR), Singapore.
2 Vascular Immunology Unit, Department of Pathology, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
3Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Address correspondence to: Samuel C. Wassmer, London School of Hygiene & Tropical Medicine, Department of Infection Biology, Keppel Street, London WC1E 7HT United Kingdom. Phone: 44.20.7612.7888; Email: sam.wassmer@lshtm.ac.uk.
Find articles by Grau, G. in: JCI | PubMed | Google Scholar
1Singapore Immunology Network, Agency for Science, Technology, and Research (A*STAR), Singapore.
2 Vascular Immunology Unit, Department of Pathology, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
3Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Address correspondence to: Samuel C. Wassmer, London School of Hygiene & Tropical Medicine, Department of Infection Biology, Keppel Street, London WC1E 7HT United Kingdom. Phone: 44.20.7612.7888; Email: sam.wassmer@lshtm.ac.uk.
Find articles by
Wassmer, S.
in:
JCI
|
PubMed
|
Google Scholar
|
First published February 17, 2020 - More info
J Clin Invest. 2020;130(3):1109–1111. https://doi.org/10.1172/JCI135510.
© 2020 American Society for Clinical Investigation
Mosquito-transmitted Plasmodium falciparum infection can cause human cerebral malaria (HCM) with high mortality rates. The abundance of infected red blood cells that accumulate in the cerebral vasculature of patients has led to the belief that these brain-sequestered cells solely cause pathogenesis. However, animal models suggest that CD8+ T cells migrate to and accumulate in the brain, directly contributing to experimental cerebral malaria (ECM) mortality. In this issue of the JCI, Riggle et al. explored the brain vasculature from 34 children who died from HCM or other causes and frequently found CD3+ CD8+ T cells in contact with endothelial cells. Further, the authors show that coinfection with HIV enhanced such CD3+ CD8+ T cell luminal distribution. These findings suggest that the mouse model for cerebral malaria may accurately reflect human disease pathology. This study sheds new light on the mechanisms behind blood-brain barrier breakdown in this complicated neurological disease and opens up alternative approaches for treatment.
- Purchase this article
- $10
- Purchasing this article will give you full access for the calendar year.
- Purchase Site Pass
- $25
- This will give you access to every article on the site for 24 hours.
- Online subscription
- $95
- Individual online subscriptions give you full online access for the calendar year.
- Individual online subscriptions ordered from September 1st on will receive access for the remainder of current year as well as for the full following year subscription term.
- Print subscription
- $830
- Individual print subscriptions give you the print journal and full online access for the year.
- JCI This Month subscription
- $125
- JCI This Month is a 16- to 20-page overview of the articles published each month
- Subscribing to JCI This Month also gives subscribers full online access for the calendar year.
- *Price outside U.S. and Canada: $225.
Copyright © 2020 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)