Review Series 10.1172/JCI129192

Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis

Geneviève Marcelin,1 Ana Letícia M. Silveira,1,2 Laís Bhering Martins,1,2 Adaliene V.M. Ferreira,2 and Karine Clément1,3

1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.

2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.

Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).

Authorship note: ALMS and LBM contributed equally to this work.

Find articles by Marcelin, G. in: JCI | PubMed | Google Scholar

1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.

2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.

Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).

Authorship note: ALMS and LBM contributed equally to this work.

Find articles by Silveira, A. in: JCI | PubMed | Google Scholar

1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.

2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.

Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).

Authorship note: ALMS and LBM contributed equally to this work.

Find articles by Martins, L. in: JCI | PubMed | Google Scholar

1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.

2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.

Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).

Authorship note: ALMS and LBM contributed equally to this work.

Find articles by Ferreira, A. in: JCI | PubMed | Google Scholar

1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.

2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.

Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).

Authorship note: ALMS and LBM contributed equally to this work.

Find articles by Clément, K. in: JCI | PubMed | Google Scholar

First published September 9, 2019 - More info

J Clin Invest. https://doi.org/10.1172/JCI129192.
© 2019 American Society for Clinical Investigation
First published September 9, 2019 - Version history

Obesity originates from an imbalance between caloric intake and energy expenditure that promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients with higher visceral fat mass are at a higher risk of developing severe complications such as type 2 diabetes and cardiovascular and liver diseases. However, increased fat mass does not fully explain obesity’s propensity to promote metabolic diseases. With chronic obesity, adipose tissue undergoes major remodeling, which can ultimately result in unresolved chronic inflammation leading to fibrosis accumulation. These features drive local tissue damage and initiate and/or maintain multiorgan dysfunction. Here, we review the current understanding of adipose tissue remodeling with a focus on obesity-induced adipose tissue fibrosis and its relevance to clinical manifestations.

Preview pages

Reset
Next Page 0 Back

Continue reading with a subscription.

A subscription is required for you to read this article in full. If you are a subscriber, you may sign in to continue reading.

Already subscribed?

Click here to sign into your account.

Don't have a subscription?

Please select one of the subscription options, which includes a low-cost option just for this article.

At an institution or library?

If you are at an institution or library and believe you should have access, please check with your librarian or administrator (more information).

Problems?

Please try these troubleshooting tips.

  • Purchase this article
  • $10
  • Purchasing this article will give you full access for the calendar year.
  • Purchase article
  • Purchase Site Pass
  • $25
  • This will give you access to every article on the site for 24 hours.
  • Order site pass
  • Online subscription
  • $95
  • Individual online subscriptions give you full online access for the calendar year.
  • Order Online
  • Print subscription
  • $795
  • Individual print subscriptions give you the print journal and full online access for the year.
  • Print + Online
  • JCI This Month subscription
  • $125
  • JCI This Month is a 16- to 20-page overview of the articles published each month
  • Subscribing to JCI This Month also gives subscribers full online access for the calendar year.
  • *Price outside U.S. and Canada: $225.
  • JCI This Month + Online
Advertisement