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The L-type calcium channel current modulation mechanism: the plot thickens and fogs
Brooke M. Ahern, Jonathan Satin
Brooke M. Ahern, Jonathan Satin
Published January 7, 2019
Citation Information: J Clin Invest. 2019;129(2):496-498. https://doi.org/10.1172/JCI125958.
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Commentary

The L-type calcium channel current modulation mechanism: the plot thickens and fogs

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Abstract

Stressful situations provoke the fight-or-flight response, incurring rapid elevation of cardiac output via activation of protein kinase A (PKA). In this issue of the JCI, Yang et al. focus on the L-type calcium channel complex (LTCC), and their findings require reexamination of dogmatic principles. LTCC phosphorylation sites identified and studied to date are dispensable for PKA modulation of LTCC; however, a CaVβ2-CaV1.2 calcium channel interaction is now shown to be required. Yang et al. suggest a new hypothesis that LTCC modulation involves rearrangement of auxiliary proteins within the LTCC. However, we still do not know the targets of PKA that mediate LTCC modulation.

Authors

Brooke M. Ahern, Jonathan Satin

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